VMDirectPath allows guest operating systems to directly access an I/O device, bypassing the virtualization layer. This direct path, or passthrough can improve performance for VMware ESX systems that utilize high-speed I/O devices, such as 10 Gigabit Ethernet.

VMDirectPath supports a direct device connection for virtual machines running on Intel Xeon 5500 systems, which feature an implementation of the I/O memory management unit (IOMMU) called Virtual Technology for Directed I/O (VT‐d). VMDirectPath can work on AMD platforms with I/O Virtualization Technology (AMD IOMMU), but this configuration is offered as experimental support.